Mercury in fish harms immune system.

Sep 28, 2011

Nyland, JF, M Fillion, F Barbosa, Jr., DL Shirley, C Chine, M Lemire, D Mergler and EK Silbergeld. 2011. Biomarkers of  methyl mercury exposure immunotoxicity among fish consumers in Amazonian Brazil. Environmental Health Perspectives http://dx.doi.org/10.1289./ehp.1103741
 



Synopsis by Roxanne Karimi and Wendy Hessler

2011-0927eatenfish
Paul-in-London/flickr
Adults exposed to methylmercury through a fish diet have immune system changes similar to those seen in more highly exposed gold mine workers, according to a study of Brazilians living in the Amazon River Basin.

The results from the fish-eating exposures could be relevant to other places, including those in the United States where people regularly eat fish with higher mercury levels.

The results show that immune system effects are not limited to those who are highly exposed through gold mining jobs, but also occur in adults who eat fish contaminated with higher levels of mercury. The nutrient selenium – with its long-debated role in immune function – offered no clear protection against the mercury induced changes.

The findings add more details of how mercury alters the immune system and specific antibodies in those exposed to the pollutant through diet. Whether these changes in the immune system lead to health problems is unknown.


Context

Fish are one of the healthiest sources of protein and contain high amounts of other nutrients, namely omega-3 fatty acids, which benefit brain development and cardiovascular health.

However, all fish are contaminanted with mercury to some extent. Mercury is a naturally-occurring element in rock and soils. Some human processes – such as burning coal in coal-fired power plants – redistribute mercury in the environment by releasing it into the atmosphere. From the atmosphere, mercury enters waterbodies where organisms take up the mercury and pass it along the food chain.

Methylmercury, the dominant form found in fish, builds up in the body over time, potentially reaching toxic levels. It also increases in concentration as it goes up the food chain. So, even trace amounts of mercury in the water can lead to high concentrations in fish – especially long-lived species and top predators.

Methylmercury impairs development of the nervous system and can harm humans and wildlife in high doses. Mercury exposure is also linked to immune system changes. These changes include altered levels of antibodies and cytokines associated with autoimmune dysfunction such as lupus.

These effects were seen in gold miners in Brazil's Amazon who have some of the highest mercury exposures in this region, due to direct exposure at work and from eating contaminated fish. Mercury pollution in the Amazon River Basin is widespread. Soil erosion from deforestation carries the naturally-ocurring metal into rivers. Gold mining – which uses mercury to extract the gold flakes – contributes huge amounts of mercury to the ecosystem. Studies in these areas of Brazil report a number of health problems in the exposed population, including developmental, motor and cognitive deficits.

Still, experts generally recommend fish as part of a healthy diet. Consumers can follow government dietary guidelines, while pregnant women and children who are more at risk should follow the stricter guidelines

What did they do?

Researchers measured methylmercury, selenium and different immune factors in more than 200 adults living next to the Tapajós River in the Brazilian Amazon. The residents in this region who do not work directly in gold mining are exposed to mercury mainly from eating fish.

Methylmercury and selenium were measured in the blood, hair and urine. Selenium was measured to see if it altered the immune response to mercury. Their concentrations were compared to levels of a variety of immune factors in the blood.

The scientists measured two immune system factors – known as autoantibodies – that fight the body’s own cells and indicate autoimmune diseases. They also measured eight cytokines, which circulate throughout the body and indicate inflammatory responses.

Personal information, health problems and job history were self-reported through questionnaires.

What did they find?

The scientists found a clear link between the types and amounts of autoantibodies and mercury levels in individuals who eat fish. Mercury exposure from eating fish was lower than exposure in gold miners. These immune responses were similar to those in previous studies of adults with higher mercury exposure from both gold mining and from eating contaminated fish.

The mercury levels measured in the blood in this study were similar to those found in the U.S. population, but the maximum levels recorded were generally higher. This is likely due to higher fish consumption rates and higher mercury concentrations in the Amazonian fish when compared to U.S. fish. 

Subjects with elevated methylmercury exposure had elevated levels of one of the autoantibodies measured in their blood (ANA). However, there was no association with the other antibody (ANoA). Methylmercury exposure was also associated with changes in cytokine levels, but the type of change (increase or decrease) depended on the ANA response.

While selenium exposure was strongly related to methylmercury exposure, selenium had no effect on any of the immune responses measured. This was the case even at normal to high selenium exposure levels.

What does it mean?

Mercury exposure is linked to immune system changes in adults who eat fish from a river in Brazil that has a history of methylmercury pollution. These immune responses closely align with immune responses seen in the more highly-exposed gold miners from the same area near the Tapajós River in the Brazilian Amazon.

The results suggest that changes in immune system factors due to mercury are not limited to the more highly exposed gold miners, but also extend to adults who are mainly exposed to mercury from eating fish.  

The study is part of a larger, longer research effort looking at mercury exposure and human health impacts in this region of Brazil.

Findings from this study add evidence to the growing body of research showing the effects of mercury on immune system factors, even in individuals with lower mercury exposure levels.

This study identifies details about the immune response and finds again that only one of the two antibodies measured – ANA – was linked to the mercury exposure. Mercury exposure triggered other immune responders called cytokines. No clear trends were seen as both pro- or anti-inflammatory types increased. These results may indicate that different individuals react differently to the exposures.

A puzzle for researchers is the relationship between mercury and selenium– another element found in in fish. Some studies suggest the selenium can counteract mercury's toxic effects while other studies dispute that idea. In this study, selenium had no effect on either mercury or immune function.

Further research is necessary to examine the whether these immunological changes identified in this study can occur at lower levels of mercury exposure or can lead to toxic health effects.

Resources

Bajek, F. Gold rush brings heavy cost to Peru's environment. Associated Press. Sunday, June 26, 2011

Gardner RM, Nyland JF, Silva IA, Ventura AM, de Souza JM, Silbergeld EK. 2010b. Mercury
exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brasil: a cross-sectional study
. Environmental Research 110(4):345-354.

Passos, CJ and D Mergler. 2008. Human mercury exposure and adverse health effects in the Amazon: a review. Cad. Saúde Pública 24 Suppl 4:s503-520.

 

 

 

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